April 26, 2017

DIPG histopathology and more about


Recent studies...have provided a breadth of evidence highlighting the unique molecular genetics and epigenetics of this cancer, distinguishing it from both adult and pediatric cerebral high-grade astrocytomas. 

DIPG Histopathology

Diffuse intrinsic pontine glioma is a heterogeneous disease, and represents a varied histological spectrum. These tumors are very diffuse and often involve adjacent brain structures beyond the pons.

Several studies report it spreading beyond pons...in as many as one-third of DIPG, tumor cells found as far rostrally as the FRONTAL LOBE (!)

A review...on 108 biopsies from 13 studies, including 37 AA (WHO grade III), 27 GBM(WHO grade IV), 22 LGA (WHO grade II), 3 anaplastic oligoastrocytomas (WHO grade III), and 19 tumors with “not further specified” or undefined characterization.

Data suggest that WHO grade III AA- anaplastic astrocytoma - are the most common histological entity in brainstem glioma; however, autopsy based histopathological studies report WHO grade IV GBM to be the most common histology.

Of the 33 pediatric patients, 29 were reported to be GBM and 4 with anaplastic astrocytoma histology.

Abother source reported 42 GBM, 18 anaplastic astrocytoma, 8 low-grade astrocytoma, and 2 with features of primitive neuroectodermal tumor (PNET, WHO grade IV).

Importantly, reginal differencies WITHIN ONE DIPG specimen, can bias biopsy based diagnoses. Autopsy studies allow extensive tissue sampling and have highlighted intratumoral histopathologic heterogeneity. Areas within or around a grade IV astrocytoma may present with features of grade II or grade III histology that could be inadvertently targeted at biopsy.

Perhaps most importantly, DIPG histology is not a predictor of survival. Patients with low-grade histology do just as poorly as patients with high-grade histology (which is in striking contrast to the family of gliomas, where it's grade determines survival:
--- grade II - 5-7 years median survival
--- grade III - 3-4 years
--- grade IV - 15 months for glioblastomas)

Advanced neuroblastoma case, distant healing


Very tough and, don't want to say that, near hopeless case of neuroblastoma, where a boy was given just 2 months, "if treatment fails" and it failed. Also failed the immunotherapy, which was the ultimate hope.

Yet he's living beyond this mark, for more than 1.5 months, which still doesn't guarantee anything, so far this case is a collection of all unfavourable factors regarding cancer, first of all, what makes cancer nearly incurable from the very beginning = critical energy deficit of fundamental level, where cancer takes roots.

DIPG case, distant healing, update


Positive shifts:
"...Zamora has begun her hyperbaric treatment! She has had two sessions ( ok she is not looking so happy in this photo, but I guarantee she's a rockstar) and she is already sticking her tongue out further and raising her right arm which she cannot really move"
" Check out this amazing video we just took of Zamora! She is moving her right arm so much today!"

The necrotic tissue removal by this, surely is makingn her better for impaired brain functions.

However, this is overall very tough case and I'm still not sure it can be healed,
--- it's very advanced stage - 22 months of survival
--- her energy is seriously depleted by intense previous treatments
--- she has less favourable situation for energy available on fundamental levels, than a girl reported in previous entry.

Time Energies scheme for her case, cancer start:




DIPG case, distant healing, update


Time Energies scheme for her case, date of cancer start:


Her face definitely getting more smooth and relaxed, and more symmetrical, which indicates how strong tumor is pressing the brain stem


Assymmetry and tension less, strabismus for eyes visible

24 April:

Face getting less tension on

25 April:

It's almost "normal smile" though of course its' still a long road to become normal.

The case looks solvable for complete healing, because DIPG is no different or special for energy medicine, and has the same fundamental features, as ANY OTHER CANCER ON ENERGY LEVEL. 

It's of course mainly glioblastoma histologically = glioma grade 4 = most aggressive and resistant to treatment - if there was anything except radiation, which gives only temporary relief. On the other hand, surgery and chemo possible in case of glioblastoma multiforme, also doesn't make the positive outcome:
--- DIPG median survival - 9 to 11 months (different sources)
--- glioblastoma multiforme - 15 months

She has all chances to beat it, because:
--- DIPG is on relatively EARLY stage
--- she is strong and her immune system/energy still not destroyed by treatments
--- she seems to not have a critical energy deficit on fundamental level, which makes cancer difficult or incurable by standard treatments

Which is different for another DIPG case, next post.